Intrinsic DNA damage repair deficiency results in progressive microglia loss and replacement

The DNA excision repair protein Ercc1 is important for nucleotide excision, double strand DNA break, and interstrand DNA crosslink repair. In constitutive Ercc1‐knockout mice, microglia display increased phagocytosis, proliferation and an enhanced responsiveness to lipopolysaccharide (LPS)‐induced p...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaoming, Heng, Yang, Kooistra, Susanne M., van Weering, Hilmar R. J., Brummer, Maaike L., Gerrits, Emma, Wesseling, Evelyn M., Brouwer, Nieske, Nijboer, Tjalling W., Dubbelaar, Marissa L., Boddeke, Erik W. G. M., Eggen, Bart J. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821301/
https://www.ncbi.nlm.nih.gov/pubmed/33068332
http://dx.doi.org/10.1002/glia.23925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821301/
https://www.ncbi.nlm.nih.gov/pubmed/33068332
http://dx.doi.org/10.1002/glia.23925

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