Impaired muscle mitochondrial energetics is associated with uremic metabolite accumulation in chronic kidney disease

Chronic kidney disease (CKD) causes progressive skeletal myopathy involving atrophy, weakness, and fatigue. Mitochondria have been thought to contribute to skeletal myopathy; however, the molecular mechanisms underlying muscle metabolism changes in CKD are unknown. We employed a comprehensive mitoch...

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Detalles Bibliográficos
Autores principales: Thome, Trace, Kumar, Ravi A., Burke, Sarah K., Khattri, Ram B., Salyers, Zachary R., Kelley, Rachel C., Coleman, Madeline D., Christou, Demetra D., Hepple, Russell T., Scali, Salvatore T., Ferreira, Leonardo F., Ryan, Terence E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821598/
https://www.ncbi.nlm.nih.gov/pubmed/33290279
http://dx.doi.org/10.1172/jci.insight.139826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821598/
https://www.ncbi.nlm.nih.gov/pubmed/33290279
http://dx.doi.org/10.1172/jci.insight.139826

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