Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells

BACKGROUND: Aerobic glycolysis, discovered by Otto Warburg, is a hallmark of cancer metabolism even though not yet fully understood. The low activity of the cancerous pyruvate kinase isozyme (M2) is thought to play an important role by facilitating the conversion of glycolytic intermediates to other...

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Detalles Bibliográficos
Autores principales: Almouhanna, Fadi, Blagojevic, Biljana, Can, Suzan, Ghanem, Ali, Wölfl, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821649/
https://www.ncbi.nlm.nih.gov/pubmed/33482908
http://dx.doi.org/10.1186/s40170-021-00239-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821649/
https://www.ncbi.nlm.nih.gov/pubmed/33482908
http://dx.doi.org/10.1186/s40170-021-00239-8

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