SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice

BACKGROUND: Sirtuin 6 (SIRT6) is a NAD(+)-dependent deacetylase with key roles in cell metabolism. High SIRT6 expression is associated with adverse prognosis in breast cancer (BC) patients. However, the mechanisms through which SIRT6 exerts its pro-oncogenic effects in BC remain unclear. Here, we so...

Descripción completa

Detalles Bibliográficos
Autores principales: Becherini, Pamela, Caffa, Irene, Piacente, Francesco, Damonte, Patrizia, Vellone, Valerio G., Passalacqua, Mario, Benzi, Andrea, Bonfiglio, Tommaso, Reverberi, Daniele, Khalifa, Amr, Ghanem, Moustafa, Guijarro, Ana, Tagliafico, Luca, Sucameli, Marzia, Persia, Angelica, Monacelli, Fiammetta, Cea, Michele, Bruzzone, Santina, Ravera, Silvia, Nencioni, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821730/
https://www.ncbi.nlm.nih.gov/pubmed/33482921
http://dx.doi.org/10.1186/s40170-021-00240-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821730/
https://www.ncbi.nlm.nih.gov/pubmed/33482921
http://dx.doi.org/10.1186/s40170-021-00240-1

Ejemplares similares