Growth of pancreatic cancers with hemizygous chromosomal 17p loss of MYBBP1A can be preferentially targeted by PARP inhibitors

Here, we selectively target pancreatic ductal adenocarcinoma (PDAC) cells harboring a hemizygous gene essential for cell growth. MYB binding protein 1A (MYBBP1A), encoding a chromatin-bound protein, is hemizygous in most of the PDAC due to a chromosome 17p deletion that also spans TP53. We find that...

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Detalles Bibliográficos
Autores principales: Hsieh, Antony, Pitarresi, Jason R., Lerner, Jonathan, Donahue, Greg, Hsiehchen, David, Rustgi, Anil K., Zaret, Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821900/
https://www.ncbi.nlm.nih.gov/pubmed/33277249
http://dx.doi.org/10.1126/sciadv.abc4517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821900/
https://www.ncbi.nlm.nih.gov/pubmed/33277249
http://dx.doi.org/10.1126/sciadv.abc4517

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