Sterol 14α-Demethylase Ligand-Binding Pocket-Mediated Acquired and Intrinsic Azole Resistance in Fungal Pathogens

The fungal cytochrome P450 enzyme sterol 14α-demethylase (SDM) is a key enzyme in the ergosterol biosynthesis pathway. The binding of azoles to the active site of SDM results in a depletion of ergosterol, the accumulation of toxic intermediates and growth inhibition. The prevalence of azole-resistan...

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Detalles Bibliográficos
Autores principales: Rosam, Katharina, Monk, Brian C., Lackner, Michaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822023/
https://www.ncbi.nlm.nih.gov/pubmed/33374996
http://dx.doi.org/10.3390/jof7010001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822023/
https://www.ncbi.nlm.nih.gov/pubmed/33374996
http://dx.doi.org/10.3390/jof7010001

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