Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation

The discovery of multi-targeting ligands of bacterial enzymes is an important strategy to combat rapidly spreading antimicrobial resistance. Bacterial DNA gyrase and topoisomerase IV are validated targets for the development of antibiotics. They can be inhibited at their catalytic sites or at their...

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Detalles Bibliográficos
Autores principales: Durcik, Martina, Skok, Žiga, Ilaš, Janez, Zidar, Nace, Zega, Anamarija, Szili, Petra Éva, Draskovits, Gábor, Révész, Tamás, Kikelj, Danijel, Nyerges, Akos, Pál, Csaba, Mašič, Lucija Peterlin, Tomašič, Tihomir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822030/
https://www.ncbi.nlm.nih.gov/pubmed/33374964
http://dx.doi.org/10.3390/pharmaceutics13010006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822030/
https://www.ncbi.nlm.nih.gov/pubmed/33374964
http://dx.doi.org/10.3390/pharmaceutics13010006

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