Discovery of indole-3-butyric acid derivatives as potent histone deacetylase inhibitors

In discovery of HDAC inhibitors (HDACIs) with improved anticancer potency, structural modification was performed on the previous derived indole-3-butyric acid derivative. Among all the synthesised compounds, molecule I13 exhibited high HDAC inhibitory and antiproliferative potencies in the in vitro...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Yiming, Zhang, Lihui, Zhang, Lin, Jiang, Qixiao, Zhang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822065/
https://www.ncbi.nlm.nih.gov/pubmed/33445997
http://dx.doi.org/10.1080/14756366.2020.1870457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822065/
https://www.ncbi.nlm.nih.gov/pubmed/33445997
http://dx.doi.org/10.1080/14756366.2020.1870457

Ejemplares similares