Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates

The pyridinium-2-carbaldoximes with quinolinium carboxamide moiety were designed and synthesised as cholinesterase reactivators. The prepared compounds showed intermediate-to-high inhibition of both cholinesterases when compared to standard oximes. Their reactivation ability was evaluated in vitro o...

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Detalles Bibliográficos
Autores principales: Lee, Hyun Myung, Andrys, Rudolf, Jonczyk, Jakub, Kim, Kyuneun, Vishakantegowda, Avinash G., Malinak, David, Skarka, Adam, Schmidt, Monika, Vaskova, Michaela, Latka, Kamil, Bajda, Marek, Jung, Young-Sik, Malawska, Barbara, Musilek, Kamil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822067/
https://www.ncbi.nlm.nih.gov/pubmed/33467931
http://dx.doi.org/10.1080/14756366.2020.1869954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822067/
https://www.ncbi.nlm.nih.gov/pubmed/33467931
http://dx.doi.org/10.1080/14756366.2020.1869954

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