Oxidative Stress, Glutathione Metabolism, and Liver Regeneration Pathways Are Activated in Hereditary Tyrosinemia Type 1 Mice upon Short-Term Nitisinone Discontinuation

Hereditary tyrosinemia type 1 (HT1) is an inherited condition in which the body is unable to break down the amino acid tyrosine due to mutations in the fumarylacetoacetate hydrolase (FAH) gene, coding for the final enzyme of the tyrosine degradation pathway. As a consequence, HT1 patients accumulate...

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Detalles Bibliográficos
Autores principales: Colemonts-Vroninks, Haaike, Neuckermans, Jessie, Marcelis, Lionel, Claes, Paul, Branson, Steven, Casimir, Georges, Goyens, Philippe, Martens, Geert A., Vanhaecke, Tamara, De Kock, Joery
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822164/
https://www.ncbi.nlm.nih.gov/pubmed/33375092
http://dx.doi.org/10.3390/genes12010003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822164/
https://www.ncbi.nlm.nih.gov/pubmed/33375092
http://dx.doi.org/10.3390/genes12010003

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