In situ kinetic measurements of α-synuclein aggregation reveal large population of short-lived oligomers

Knowledge of the mechanisms of assembly of amyloid proteins into aggregates is of central importance in building an understanding of neurodegenerative disease. Given that oligomeric intermediates formed during the aggregation reaction are believed to be the major toxic species, methods to track such...

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Detalles Bibliográficos
Autores principales: Zurlo, Enrico, Kumar, Pravin, Meisl, Georg, Dear, Alexander J., Mondal, Dipro, Claessens, Mireille M. A. E., Knowles, Tuomas P. J., Huber, Martina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822277/
https://www.ncbi.nlm.nih.gov/pubmed/33481908
http://dx.doi.org/10.1371/journal.pone.0245548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822277/
https://www.ncbi.nlm.nih.gov/pubmed/33481908
http://dx.doi.org/10.1371/journal.pone.0245548

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