The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans

Osteocalcin (OCN) is an osteoblast-derived hormone with pleiotropic physiological functions. Like many peptide hormones, OCN is subjected to post-translational modifications (PTMs) which control its activity. Here, we uncover O-glycosylation as a novel PTM present on mouse OCN and occurring on a sin...

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Detalles Bibliográficos
Autores principales: Al Rifai, Omar, Julien, Catherine, Lacombe, Julie, Faubert, Denis, Lira-Navarrete, Erandi, Narimatsu, Yoshiki, Clausen, Henrik, Ferron, Mathieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822592/
https://www.ncbi.nlm.nih.gov/pubmed/33284103
http://dx.doi.org/10.7554/eLife.61174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822592/
https://www.ncbi.nlm.nih.gov/pubmed/33284103
http://dx.doi.org/10.7554/eLife.61174

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