SHANK2 mutations impair apoptosis, proliferation and neurite outgrowth during early neuronal differentiation in SH-SY5Y cells

SHANK2 mutations have been identified in individuals with neurodevelopmental disorders, including intellectual disability and autism spectrum disorders (ASD). Using CRISPR/Cas9 genome editing, we obtained SH-SY5Y cell lines with frameshift mutations on one or both SHANK2 alleles. We investigated the...

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Detalles Bibliográficos
Autores principales: Unsicker, Christine, Cristian, Flavia-Bianca, von Hahn, Manja, Eckstein, Volker, Rappold, Gudrun A., Berkel, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822837/
https://www.ncbi.nlm.nih.gov/pubmed/33483523
http://dx.doi.org/10.1038/s41598-021-81241-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822837/
https://www.ncbi.nlm.nih.gov/pubmed/33483523
http://dx.doi.org/10.1038/s41598-021-81241-4

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