Cargando…

Integrative computational approach identifies drug targets in CD4(+) T-cell-mediated immune disorders

CD4(+) T cells provide adaptive immunity against pathogens and abnormal cells, and they are also associated with various immune-related diseases. CD4(+) T cells’ metabolism is dysregulated in these pathologies and represents an opportunity for drug discovery and development. Genome-scale metabolic m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Puniya, Bhanwar Lal, Amin, Rada, Lichter, Bailee, Moore, Robert, Ciurej, Alex, Bennett, Sydney J., Shah, Ab Rauf, Barberis, Matteo, Helikar, Tomáš
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822845/ https://www.ncbi.nlm.nih.gov/pubmed/33483502 http://dx.doi.org/10.1038/s41540-020-00165-3

Ejemplares similares

A multi-approach and multi-scale platform to model CD4+ T cells responding to infections
por: Wertheim, Kenneth Y., et al.
Publicado: (2021)

A multiscale mechanistic model of human dendritic cells for in-silico investigation of immune responses and novel therapeutics discovery
por: Aghamiri, Sara Sadat, et al.
Publicado: (2023)

A Mechanistic Computational Model Reveals That Plasticity of CD4(+) T Cell Differentiation Is a Function of Cytokine Composition and Dosage
por: Puniya, Bhanwar Lal, et al.
Publicado: (2018)

Systems Perturbation Analysis of a Large-Scale Signal Transduction Model Reveals Potentially Influential Candidates for Cancer Therapeutics
por: Puniya, Bhanwar Lal, et al.
Publicado: (2016)

Identification of Biologically Essential Nodes via Determinative Power in Logical Models of Cellular Processes
por: Pentzien, Trevor, et al.
Publicado: (2018)

Author Correction: Integrative network analyses of transcriptomics data reveal potential drug targets for acute radiation syndrome
por: Moore, Robert, et al.
Publicado: (2021)

Integrative network analyses of transcriptomics data reveal potential drug targets for acute radiation syndrome
por: Moore, Robert, et al.
Publicado: (2021)

Arginine Catabolism and Polyamine Biosynthesis Pathway Disparities Within Francisella tularensis Subpopulations
por: Yue, Yinshi, et al.
Publicado: (2022)

Differences in Blood-Derived Francisella tularensis Type B Strains from Clinical Cases of Tularemia
por: Larson, Marilynn A., et al.
Publicado: (2020)

Fish Oil Intake During Gestation and Lactation Attenuated STZ-Induced Diabetes in Male Offspring via Activation of Brown Fat and Modulating Oxylipin Profile
por: Fan, Rong, et al.
Publicado: (2022)

Identification of Novel Adhesins of M. tuberculosis H37Rv Using Integrated Approach of Multiple Computational Algorithms and Experimental Analysis
por: Kumar, Sanjiv, et al.
Publicado: (2013)

Corrigendum: Integration of Metabolic Modeling with Gene Co-expression Reveals Transcriptionally Programmed Reactions Explaining Robustness in Mycobacterium tuberculosis
por: Puniya, Bhanwar Lal, et al.
Publicado: (2016)

Integration of Metabolic Modeling with Gene Co-expression Reveals Transcriptionally Programmed Reactions Explaining Robustness in Mycobacterium tuberculosis
por: Puniya, Bhanwar Lal, et al.
Publicado: (2016)

Recent applications of quantitative systems pharmacology and machine learning models across diseases
por: Aghamiri, Sara Sadat, et al.
Publicado: (2021)

De Novo Transcriptome Sequencing Reveals Important Molecular Networks and Metabolic Pathways of the Plant, Chlorophytum borivilianum
por: Kalra, Shikha, et al.
Publicado: (2013)

Simulation of Stimulation: Cytokine Dosage and Cell Cycle Crosstalk Driving Timing-Dependent T Cell Differentiation
por: Barberis, Matteo, et al.
Publicado: (2018)

Factors Influencing Instructors’ Adoption and Continued Use of Computing Science Technologies: A Case Study in the Context of Cell Collective
por: Song, Changsoo, et al.
Publicado: (2023)

T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders
por: Rani, Jyoti, et al.
Publicado: (2017)

Stomiosphaerina bakae sp. nov., a new calcareous dinocyst of the Upper Cretaceous of the Central European Basin
por: Ciurej, Agnieszka
Publicado: (2023)

Comparison of lower loading dose of prasugrel with conventional loading dose of prasugrel in Indian patients undergoing percutaneous coronary interventions
por: Kumari, Priti, et al.
Publicado: (2018)

Simulating a Computational Biological Model, Rather Than Reading, Elicits Changes in Brain Activity during Biological Reasoning
por: Clark, Caron A. C., et al.
Publicado: (2020)

SysMod: the ISCB community for data-driven computational modelling and multi-scale analysis of biological systems
por: Dräger, Andreas, et al.
Publicado: (2021)

The Need for Research-Grade Systems Modeling Technologies for Life Science Education
por: Helikar, Tomáš
Publicado: (2021)

Cadosinopsis rehakovii sp. nov., a new calcareous dinocyst from the Jurassic-Cretaceous transitional interval of the Western Tethys
por: Ciurej, Agnieszka, et al.
Publicado: (2021)

Design, Assessment, and in vivo Evaluation of a Computational Model Illustrating the Role of CAV1 in CD4(+) T-lymphocytes
por: Conroy, Brittany D., et al.
Publicado: (2014)

Calcareous dinoflagellate blooms during the Late Cretaceous ‘greenhouse’ world—a case study from western Ukraine
por: Ciurej, Agnieszka, et al.
Publicado: (2023)

Integrating Interactive Computational Modeling in Biology Curricula
por: Helikar, Tomáš, et al.
Publicado: (2015)

Teaching Metabolism in Upper-Division Undergraduate Biochemistry Courses using Online Computational Systems and Dynamical Models Improves Student Performance
por: Booth, Christine S., et al.
Publicado: (2021)

Ergodic Sets as Cell Phenotype of Budding Yeast Cell Cycle
por: Todd, Robert G., et al.
Publicado: (2012)

ChemChains: a platform for simulation and analysis of biochemical networks aimed to laboratory scientists
por: Helikar, Tomáš, et al.
Publicado: (2009)

Potassium permanganate toxicity: A rare case with difficult airway management and hepatic damage
por: Agrawal, Vijay Kumar, et al.
Publicado: (2014)

Computational Systems Biology Approach for the Study of Rheumatoid Arthritis: From a Molecular Map to a Dynamical Model
por: Singh, Vidisha, et al.
Publicado: (2017)

Aluminum phosphide poisoning: Possible role of supportive measures in the absence of specific antidote
por: Agrawal, Vijay Kumar, et al.
Publicado: (2015)

Identification of potential tissue-specific cancer biomarkers and development of cancer versus normal genomic classifiers
por: Mohammed, Akram, et al.
Publicado: (2017)

CancerDiscover: an integrative pipeline for cancer biomarker and cancer class prediction from high-throughput sequencing data
por: Mohammed, Akram, et al.
Publicado: (2017)

Strongly separated pairs of core electrons in computed ground states of small molecules
por: Gottlieb, Alex D., et al.
Publicado: (2013)

Acute Fulminant Uremic Neuropathy Following Coronary Angiography Mimicking Guillain–Barre Syndrome
por: Priti, Kumari, et al.
Publicado: (2017)

The CoLoMoTo Interactive Notebook: Accessible and Reproducible Computational Analyses for Qualitative Biological Networks
por: Naldi, Aurélien, et al.
Publicado: (2018)

Addressing barriers in comprehensiveness, accessibility, reusability, interoperability and reproducibility of computational models in systems biology
por: Niarakis, Anna, et al.
Publicado: (2022)

Transulnar versus Transradial Access as a Default Strategy for Percutaneous Coronary Intervention
por: Ranwa, Bhanwar L., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_n1dts8bmbb2o9t9vdmscjtutln