CSN6 promotes melanoma proliferation and metastasis by controlling the UBR5-mediated ubiquitination and degradation of CDK9

As a critical subunit of the constitutive photomorphogenesis 9 (COP9) signalosome (CSN), CSN6 is upregulated in some human cancers and plays critical roles in tumorigenesis and progression, but its biological functions and molecular mechanisms in melanoma remain unknown. Our study showed that CSN6 e...

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Detalles Bibliográficos
Autores principales: Zhang, Yanli, Hou, Jianbing, Shi, Shaomin, Du, Juan, Liu, Yudong, Huang, Pan, Li, Qian, Liu, Lichao, Hu, Huanrong, Ji, Yacong, Guo, Leiyang, Shi, Yaqiong, Liu, Yaling, Cui, Hongjuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822921/
https://www.ncbi.nlm.nih.gov/pubmed/33483464
http://dx.doi.org/10.1038/s41419-021-03398-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822921/
https://www.ncbi.nlm.nih.gov/pubmed/33483464
http://dx.doi.org/10.1038/s41419-021-03398-0

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