Deubiquitylating enzymes in neuronal health and disease

Ubiquitylation and deubiquitylation play a pivotal role in protein homeostasis (proteostasis). Proteostasis shapes the proteome landscape in the human brain and its impairment is linked to neurodevelopmental and neurodegenerative disorders. Here we discuss the emerging roles of deubiquitylating enzy...

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Autores principales: Amer-Sarsour, Fatima, Kordonsky, Alina, Berdichevsky, Yevgeny, Prag, Gali, Ashkenazi, Avraham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822931/
https://www.ncbi.nlm.nih.gov/pubmed/33483467
http://dx.doi.org/10.1038/s41419-020-03361-5
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author Amer-Sarsour, Fatima
Kordonsky, Alina
Berdichevsky, Yevgeny
Prag, Gali
Ashkenazi, Avraham
author_facet Amer-Sarsour, Fatima
Kordonsky, Alina
Berdichevsky, Yevgeny
Prag, Gali
Ashkenazi, Avraham
author_sort Amer-Sarsour, Fatima
collection PubMed
description Ubiquitylation and deubiquitylation play a pivotal role in protein homeostasis (proteostasis). Proteostasis shapes the proteome landscape in the human brain and its impairment is linked to neurodevelopmental and neurodegenerative disorders. Here we discuss the emerging roles of deubiquitylating enzymes in neuronal function and survival. We provide an updated perspective on the genetics, physiology, structure, and function of deubiquitylases in neuronal health and disease. [Image: see text]
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spelling pubmed-78229312021-01-29 Deubiquitylating enzymes in neuronal health and disease Amer-Sarsour, Fatima Kordonsky, Alina Berdichevsky, Yevgeny Prag, Gali Ashkenazi, Avraham Cell Death Dis Review Article Ubiquitylation and deubiquitylation play a pivotal role in protein homeostasis (proteostasis). Proteostasis shapes the proteome landscape in the human brain and its impairment is linked to neurodevelopmental and neurodegenerative disorders. Here we discuss the emerging roles of deubiquitylating enzymes in neuronal function and survival. We provide an updated perspective on the genetics, physiology, structure, and function of deubiquitylases in neuronal health and disease. [Image: see text] Nature Publishing Group UK 2021-01-22 /pmc/articles/PMC7822931/ /pubmed/33483467 http://dx.doi.org/10.1038/s41419-020-03361-5 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Amer-Sarsour, Fatima
Kordonsky, Alina
Berdichevsky, Yevgeny
Prag, Gali
Ashkenazi, Avraham
Deubiquitylating enzymes in neuronal health and disease
title Deubiquitylating enzymes in neuronal health and disease
title_full Deubiquitylating enzymes in neuronal health and disease
title_fullStr Deubiquitylating enzymes in neuronal health and disease
title_full_unstemmed Deubiquitylating enzymes in neuronal health and disease
title_short Deubiquitylating enzymes in neuronal health and disease
title_sort deubiquitylating enzymes in neuronal health and disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822931/
https://www.ncbi.nlm.nih.gov/pubmed/33483467
http://dx.doi.org/10.1038/s41419-020-03361-5
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