Impaired formation of high-order gephyrin oligomers underlies gephyrin dysfunction-associated pathologies

Gephyrin is critical for the structure, function, and plasticity of inhibitory synapses. Gephyrin mutations have been linked to various neurological disorders; however, systematic analyses of the functional consequences of these mutations are lacking. Here, we performed molecular dynamics simulation...

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Detalles Bibliográficos
Autores principales: Kim, Seungjoon, Kang, Mooseok, Park, Dongseok, Lee, Ae-Ree, Betz, Heinrich, Ko, Jaewon, Chang, Iksoo, Um, Ji Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822942/
https://www.ncbi.nlm.nih.gov/pubmed/33532714
http://dx.doi.org/10.1016/j.isci.2021.102037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822942/
https://www.ncbi.nlm.nih.gov/pubmed/33532714
http://dx.doi.org/10.1016/j.isci.2021.102037

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