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Impaired formation of high-order gephyrin oligomers underlies gephyrin dysfunction-associated pathologies
Gephyrin is critical for the structure, function, and plasticity of inhibitory synapses. Gephyrin mutations have been linked to various neurological disorders; however, systematic analyses of the functional consequences of these mutations are lacking. Here, we performed molecular dynamics simulation...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822942/ https://www.ncbi.nlm.nih.gov/pubmed/33532714 http://dx.doi.org/10.1016/j.isci.2021.102037 |