High Dose Versus Low Dose Syngeneic Hepatocyte Transplantation in Pex1-G844D NMRI Mouse Model is Safe but Does Not Achieve Long Term Engraftment

Genetic alterations in PEX genes lead to peroxisome biogenesis disorder. In humans, they are associated with Zellweger spectrum disorders (ZSD). No validated treatment has been shown to modify the dismal natural history of ZSD. Liver transplantation (LT) improved clinical and biochemical outcomes in...

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Detalles Bibliográficos
Autores principales: Demaret, Tanguy, Evraerts, Jonathan, Ravau, Joachim, Roumain, Martin, Muccioli, Giulio G., Najimi, Mustapha, Sokal, Etienne M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823729/
https://www.ncbi.nlm.nih.gov/pubmed/33396635
http://dx.doi.org/10.3390/cells10010040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823729/
https://www.ncbi.nlm.nih.gov/pubmed/33396635
http://dx.doi.org/10.3390/cells10010040

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