An Algorithm for Nonparametric Estimation of a Multivariate Mixing Distribution with Applications to Population Pharmacokinetics

Population pharmacokinetic (PK) modeling has become a cornerstone of drug development and optimal patient dosing. This approach offers great benefits for datasets with sparse sampling, such as in pediatric patients, and can describe between-patient variability. While most current algorithms assume n...

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Detalles Bibliográficos
Autores principales: Yamada, Walter M., Neely, Michael N., Bartroff, Jay, Bayard, David S., Burke, James V., van Guilder, Mike, Jelliffe, Roger W., Kryshchenko, Alona, Leary, Robert, Tatarinova, Tatiana, Schumitzky, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823953/
https://www.ncbi.nlm.nih.gov/pubmed/33396749
http://dx.doi.org/10.3390/pharmaceutics13010042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823953/
https://www.ncbi.nlm.nih.gov/pubmed/33396749
http://dx.doi.org/10.3390/pharmaceutics13010042

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