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Antioxidant and Hypolipidemic Activity of Açai Fruit Makes It a Valuable Functional Food

Several plant extracts are acquiring increasing value because of their antioxidant activity and hypolipidemic properties. Among them, great interest has been recently paid to açai fruit as a functional food. The aim of this study was to test the ability of açai extract in reducing oxidative stress a...

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Autores principales: Pirozzi, Anna Virginia Adriana, Imbimbo, Paola, D’Agostino, Antonella, Tirino, Virginia, Finamore, Rosario, Monti, Daria Maria, Piccoli, Renata, Schiraldi, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824079/
https://www.ncbi.nlm.nih.gov/pubmed/33396456
http://dx.doi.org/10.3390/antiox10010040
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author Pirozzi, Anna Virginia Adriana
Imbimbo, Paola
D’Agostino, Antonella
Tirino, Virginia
Finamore, Rosario
Monti, Daria Maria
Piccoli, Renata
Schiraldi, Chiara
author_facet Pirozzi, Anna Virginia Adriana
Imbimbo, Paola
D’Agostino, Antonella
Tirino, Virginia
Finamore, Rosario
Monti, Daria Maria
Piccoli, Renata
Schiraldi, Chiara
author_sort Pirozzi, Anna Virginia Adriana
collection PubMed
description Several plant extracts are acquiring increasing value because of their antioxidant activity and hypolipidemic properties. Among them, great interest has been recently paid to açai fruit as a functional food. The aim of this study was to test the ability of açai extract in reducing oxidative stress and modulating lipid metabolism in vitro using different cell models and different types of stress. In fact, lipid peroxidation as evaluated in a HepG2 model was reduced five-fold when using 0.25 µg/mL of extract, and it was further reduced (20-fold) with the concentration increase up to 2.5 µg/mL. With the nonalcoholic fatty liver disease (NAFLD)in vitro model, all concentrations tested showed at least a two-fold reduced fat deposit. In addition, primary adipocytes challenged with TNF-α under hypoxic conditions to mimic the persistent subcutaneous fat, treated with açai extract showed an approximately 40% reduction of fat deposit. Overall, our results show that açai is able to counteract oxidative states in all the cell models analysed and to prevent the accumulation of lipid droplets. No toxic effects and high stability overtime were highlighted at the concentrations tested. Therefore, açai can be considered a suitable support in the prevention of different alterations of lipid and oxidative metabolism responsible for fat deposition and metabolic pathological conditions.
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spelling pubmed-78240792021-01-24 Antioxidant and Hypolipidemic Activity of Açai Fruit Makes It a Valuable Functional Food Pirozzi, Anna Virginia Adriana Imbimbo, Paola D’Agostino, Antonella Tirino, Virginia Finamore, Rosario Monti, Daria Maria Piccoli, Renata Schiraldi, Chiara Antioxidants (Basel) Article Several plant extracts are acquiring increasing value because of their antioxidant activity and hypolipidemic properties. Among them, great interest has been recently paid to açai fruit as a functional food. The aim of this study was to test the ability of açai extract in reducing oxidative stress and modulating lipid metabolism in vitro using different cell models and different types of stress. In fact, lipid peroxidation as evaluated in a HepG2 model was reduced five-fold when using 0.25 µg/mL of extract, and it was further reduced (20-fold) with the concentration increase up to 2.5 µg/mL. With the nonalcoholic fatty liver disease (NAFLD)in vitro model, all concentrations tested showed at least a two-fold reduced fat deposit. In addition, primary adipocytes challenged with TNF-α under hypoxic conditions to mimic the persistent subcutaneous fat, treated with açai extract showed an approximately 40% reduction of fat deposit. Overall, our results show that açai is able to counteract oxidative states in all the cell models analysed and to prevent the accumulation of lipid droplets. No toxic effects and high stability overtime were highlighted at the concentrations tested. Therefore, açai can be considered a suitable support in the prevention of different alterations of lipid and oxidative metabolism responsible for fat deposition and metabolic pathological conditions. MDPI 2020-12-31 /pmc/articles/PMC7824079/ /pubmed/33396456 http://dx.doi.org/10.3390/antiox10010040 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pirozzi, Anna Virginia Adriana
Imbimbo, Paola
D’Agostino, Antonella
Tirino, Virginia
Finamore, Rosario
Monti, Daria Maria
Piccoli, Renata
Schiraldi, Chiara
Antioxidant and Hypolipidemic Activity of Açai Fruit Makes It a Valuable Functional Food
title Antioxidant and Hypolipidemic Activity of Açai Fruit Makes It a Valuable Functional Food
title_full Antioxidant and Hypolipidemic Activity of Açai Fruit Makes It a Valuable Functional Food
title_fullStr Antioxidant and Hypolipidemic Activity of Açai Fruit Makes It a Valuable Functional Food
title_full_unstemmed Antioxidant and Hypolipidemic Activity of Açai Fruit Makes It a Valuable Functional Food
title_short Antioxidant and Hypolipidemic Activity of Açai Fruit Makes It a Valuable Functional Food
title_sort antioxidant and hypolipidemic activity of açai fruit makes it a valuable functional food
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824079/
https://www.ncbi.nlm.nih.gov/pubmed/33396456
http://dx.doi.org/10.3390/antiox10010040
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