The Effect of Novel Oleanolic Acid Oximes Conjugated with Indomethacin on the Nrf2-ARE And NF-κB Signaling Pathways in Normal Hepatocytes and Human Hepatocellular Cancer Cells

Nrf2 and NF-κB play a key role in inflammation-driven cancers. Conjugation of anti-inflammatory drugs with oleanolic acid oxime (OAO) may enhance their therapeutic potential as a result of downregulation of these pathways. Novel OAO derivatives conjugated with indomethacin (IND) were synthesized, an...

Descripción completa

Detalles Bibliográficos
Autores principales: Narożna, Maria, Krajka-Kuźniak, Violetta, Bednarczyk-Cwynar, Barbara, Kleszcz, Robert, Baer-Dubowska, Wanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824409/
https://www.ncbi.nlm.nih.gov/pubmed/33396453
http://dx.doi.org/10.3390/ph14010032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824409/
https://www.ncbi.nlm.nih.gov/pubmed/33396453
http://dx.doi.org/10.3390/ph14010032

Ejemplares similares