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The Effect of Novel Oleanolic Acid Oximes Conjugated with Indomethacin on the Nrf2-ARE And NF-κB Signaling Pathways in Normal Hepatocytes and Human Hepatocellular Cancer Cells

Nrf2 and NF-κB play a key role in inflammation-driven cancers. Conjugation of anti-inflammatory drugs with oleanolic acid oxime (OAO) may enhance their therapeutic potential as a result of downregulation of these pathways. Novel OAO derivatives conjugated with indomethacin (IND) were synthesized, an...

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Detalles Bibliográficos
Autores principales:	Narożna, Maria, Krajka-Kuźniak, Violetta, Bednarczyk-Cwynar, Barbara, Kleszcz, Robert, Baer-Dubowska, Wanda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824409/ https://www.ncbi.nlm.nih.gov/pubmed/33396453 http://dx.doi.org/10.3390/ph14010032

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