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Distinct p63 and p73 Protein Interactions Predict Specific Functions in mRNA Splicing and Polyploidy Control in Epithelia

Epithelial organs are the first barrier against microorganisms and genotoxic stress, in which the p53 family members p63 and p73 have both overlapping and distinct functions. Intriguingly, p73 displays a very specific localization to basal epithelial cells in human tissues, while p63 is expressed in...

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Autores principales: Rozenberg, Julian M., Rogovaya, Olga S., Melino, Gerry, Barlev, Nickolai A., Kagansky, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824480/
https://www.ncbi.nlm.nih.gov/pubmed/33375680
http://dx.doi.org/10.3390/cells10010025
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author Rozenberg, Julian M.
Rogovaya, Olga S.
Melino, Gerry
Barlev, Nickolai A.
Kagansky, Alexander
author_facet Rozenberg, Julian M.
Rogovaya, Olga S.
Melino, Gerry
Barlev, Nickolai A.
Kagansky, Alexander
author_sort Rozenberg, Julian M.
collection PubMed
description Epithelial organs are the first barrier against microorganisms and genotoxic stress, in which the p53 family members p63 and p73 have both overlapping and distinct functions. Intriguingly, p73 displays a very specific localization to basal epithelial cells in human tissues, while p63 is expressed in both basal and differentiated cells. Here, we analyse systematically the literature describing p63 and p73 protein–protein interactions to reveal distinct functions underlying the aforementioned distribution. We have found that p73 and p63 cooperate in the genome stability surveillance in proliferating cells; p73 specific interactors contribute to the transcriptional repression, anaphase promoting complex and spindle assembly checkpoint, whereas p63 specific interactors play roles in the regulation of mRNA processing and splicing in both proliferating and differentiated cells. Our analysis reveals the diversification of the RNA and DNA specific functions within the p53 family.
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spelling pubmed-78244802021-01-24 Distinct p63 and p73 Protein Interactions Predict Specific Functions in mRNA Splicing and Polyploidy Control in Epithelia Rozenberg, Julian M. Rogovaya, Olga S. Melino, Gerry Barlev, Nickolai A. Kagansky, Alexander Cells Review Epithelial organs are the first barrier against microorganisms and genotoxic stress, in which the p53 family members p63 and p73 have both overlapping and distinct functions. Intriguingly, p73 displays a very specific localization to basal epithelial cells in human tissues, while p63 is expressed in both basal and differentiated cells. Here, we analyse systematically the literature describing p63 and p73 protein–protein interactions to reveal distinct functions underlying the aforementioned distribution. We have found that p73 and p63 cooperate in the genome stability surveillance in proliferating cells; p73 specific interactors contribute to the transcriptional repression, anaphase promoting complex and spindle assembly checkpoint, whereas p63 specific interactors play roles in the regulation of mRNA processing and splicing in both proliferating and differentiated cells. Our analysis reveals the diversification of the RNA and DNA specific functions within the p53 family. MDPI 2020-12-25 /pmc/articles/PMC7824480/ /pubmed/33375680 http://dx.doi.org/10.3390/cells10010025 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rozenberg, Julian M.
Rogovaya, Olga S.
Melino, Gerry
Barlev, Nickolai A.
Kagansky, Alexander
Distinct p63 and p73 Protein Interactions Predict Specific Functions in mRNA Splicing and Polyploidy Control in Epithelia
title Distinct p63 and p73 Protein Interactions Predict Specific Functions in mRNA Splicing and Polyploidy Control in Epithelia
title_full Distinct p63 and p73 Protein Interactions Predict Specific Functions in mRNA Splicing and Polyploidy Control in Epithelia
title_fullStr Distinct p63 and p73 Protein Interactions Predict Specific Functions in mRNA Splicing and Polyploidy Control in Epithelia
title_full_unstemmed Distinct p63 and p73 Protein Interactions Predict Specific Functions in mRNA Splicing and Polyploidy Control in Epithelia
title_short Distinct p63 and p73 Protein Interactions Predict Specific Functions in mRNA Splicing and Polyploidy Control in Epithelia
title_sort distinct p63 and p73 protein interactions predict specific functions in mrna splicing and polyploidy control in epithelia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824480/
https://www.ncbi.nlm.nih.gov/pubmed/33375680
http://dx.doi.org/10.3390/cells10010025
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