Design, Synthesis and In Vitro Investigation of Novel Basic Celastrol Carboxamides as Bio-Inspired Leishmanicidal Agents Endowed with Inhibitory Activity against Leishmania Hsp90

The natural triterpene celastrol (CE) is here used as lead compound for the design and synthesis of a panel of eleven CE carboxamides that were tested in vitro for their growth inhibitory activity against Leishmania infantum and L. tropica parasites. Among them, in vitro screening identified four ba...

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Detalles Bibliográficos
Autores principales: Bassanini, Ivan, Parapini, Silvia, Ferrandi, Erica E., Gabriele, Elena, Basilico, Nicoletta, Taramelli, Donatella, Sparatore, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824787/
https://www.ncbi.nlm.nih.gov/pubmed/33466300
http://dx.doi.org/10.3390/biom11010056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824787/
https://www.ncbi.nlm.nih.gov/pubmed/33466300
http://dx.doi.org/10.3390/biom11010056

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