Cargando…

Alcohol-and-HIV-Induced Lysosomal Dysfunction Regulates Extracellular Vesicles Secretion in Vitro and in Liver-Humanized Mice

SIMPLE SUMMARY: Consumption of alcohol increases liver damage in HIV people; however, the mechanisms remain elusive. By utilizing alcohol (ethanol) exposed HIV-infected human hepatocytes liver cells and ethanol-fed liver humanized mouse model (immunodeficient mice livers harbor human hepatocytes), w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dagur, Raghubendra Singh, New-Aaron, Moses, Ganesan, Murali, Wang, Weimin, Romanova, Svetlana, Kidambi, Srivatsan, Kharbanda, Kusum K., Poluektova, Larisa Y., Osna, Natalia A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824801/ https://www.ncbi.nlm.nih.gov/pubmed/33466299 http://dx.doi.org/10.3390/biology10010029

Ejemplares similares

Alcohol Metabolism Potentiates HIV-Induced Hepatotoxicity: Contribution to End-Stage Liver Disease
por: Ganesan, Murali, et al.
Publicado: (2019)

Alcohol-Induced Lysosomal Damage and Suppression of Lysosome Biogenesis Contribute to Hepatotoxicity in HIV-Exposed Liver Cells
por: New-Aaron, Moses, et al.
Publicado: (2021)

Pancreatogenic Diabetes: Triggering Effects of Alcohol and HIV
por: New-Aaron, Moses, et al.
Publicado: (2021)

Obeticholic acid attenuates human immunodeficiency virus/alcohol metabolism-induced pro-fibrotic activation in liver cells
por: New-Aaron, Moses, et al.
Publicado: (2020)

Alcohol and HIV-Derived Hepatocyte Apoptotic Bodies Induce Hepatic Stellate Cell Activation
por: New-Aaron, Moses, et al.
Publicado: (2022)

Increased liver stiffness promotes hepatitis B progression by impairing innate immunity in CCl4-induced fibrotic HBV(+) transgenic mice
por: Bybee, Grace, et al.
Publicado: (2023)

Human immunodeficiency virus and hepatotropic viruses co-morbidities as the inducers of liver injury progression
por: Ganesan, Murali, et al.
Publicado: (2019)

Liver as a target of human immunodeficiency virus infection
por: Ganesan, Murali, et al.
Publicado: (2018)

Demethylase JMJD6 as a New Regulator of Interferon Signaling: Effects of HCV and Ethanol Metabolism
por: Ganesan, Murali, et al.
Publicado: (2017)

Hepatocyte-Specific Triggering of Hepatic Stellate Cell Profibrotic Activation by Apoptotic Bodies: The Role of Hepatoma-Derived Growth Factor, HIV, and Ethanol
por: New-Aaron, Moses, et al.
Publicado: (2023)

Human hepatocyte depletion in the presence of HIV-1 infection in dual reconstituted humanized mice
por: Dagur, Raghubendra Singh, et al.
Publicado: (2018)

Hepatitis C Virus-Infected Apoptotic Hepatocytes Program Macrophages and Hepatic Stellate Cells for Liver Inflammation and Fibrosis Development: Role of Ethanol as a Second Hit
por: Ganesan, Murali, et al.
Publicado: (2018)

Role of alcohol in pathogenesis of hepatitis B virus infection
por: Ganesan, Murali, et al.
Publicado: (2020)

Cell-to-Cell Communications in Alcohol-Associated Liver Disease
por: Osna, Natalia A., et al.
Publicado: (2022)

A Pathogenic Role of Non-Parenchymal Liver Cells in Alcohol-Associated Liver Disease of Infectious and Non-Infectious Origin
por: Kharbanda, Kusum K., et al.
Publicado: (2023)

Hepatitis C, Innate Immunity and Alcohol: Friends or Foes?
por: Osna, Natalia A., et al.
Publicado: (2015)

Bifunctional Enzyme JMJD6 Contributes to Multiple Disease Pathogenesis: New Twist on the Old Story
por: Vangimalla, Shiva Shankar, et al.
Publicado: (2017)

Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired
por: Liang, Wenjing, et al.
Publicado: (2023)

Neuronal-derived extracellular vesicles are enriched in the brain and serum of HIV-1 transgenic rats
por: Dagur, Raghubendra Singh, et al.
Publicado: (2019)

Beneficial Effects of Betaine: A Comprehensive Review
por: Arumugam, Madan Kumar, et al.
Publicado: (2021)

Multi-Organ Alcohol-Related Damage: Mechanisms and Treatment
por: Osna, Natalia A., et al.
Publicado: (2016)

Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption
por: Adams, Sophie D., et al.
Publicado: (2021)

Advances in Alcoholic Liver Disease
por: Osna, Natalia, et al.
Publicado: (2012)

Treatment options for alcoholic and non-alcoholic fatty liver disease: A review
por: Singh, Sukhpreet, et al.
Publicado: (2017)

Chronic Hepatitis B Infection: New Approaches towards Cure
por: Ogunnaike, Mojisola, et al.
Publicado: (2023)

Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury
por: Osna, Natalia A, et al.
Publicado: (2016)

MEK/ERK‐mediated oncogenic signals promote secretion of extracellular vesicles by controlling lysosome function
por: Hikita, Tomoya, et al.
Publicado: (2022)

Alcoholic Liver Disease: Pathogenesis and Current Management
por: Osna, Natalia A., et al.
Publicado: (2017)

Acute ethanol-induced liver injury is prevented by betaine administration
por: Arumugam, Madan Kumar, et al.
Publicado: (2022)

Effect of cofactors on NAFLD/NASH and MAFLD. A paradigm illustrating the pathomechanics of organ dysfunction
por: Lonardo, Amedeo, et al.
Publicado: (2022)

Insight into the Role of Extracellular Vesicles in Lysosomal Storage Disorders
por: Tancini, Brunella, et al.
Publicado: (2019)

Editorial: Alcohol-associated liver disease—From pathogenesis to treatment
por: Kharbanda, Kusum K., et al.
Publicado: (2022)

Editorial: Cell-to-cell communications in alcohol-associated, metabolic-related and viral liver diseases
por: Osna, Natalia A., et al.
Publicado: (2023)

Boosting extracellular vesicle secretion
por: Debbi, Lior, et al.
Publicado: (2022)

Abnormal Lysosomal Positioning and Small Extracellular Vesicle Secretion in Arterial Stiffening and Calcification of Mice Lacking Mucolipin 1 Gene
por: Bhat, Owais M., et al.
Publicado: (2020)

THU482 The Cholesterol Metabolite, 27-hydroxycholesterol, Enhances The Secretion Of Cancer Promoting Extracellular Vesicles By Impairing Lysosomal Integrity
por: Gupta, Anasuya Das, et al.
Publicado: (2023)

An ultralong-acting tenofovir ProTide nanoformulation achieves monthslong HBV suppression
por: Das, Srijanee, et al.
Publicado: (2022)

Mitochondrial Dysfunction-Associated Mechanisms in the Development of Chronic Liver Diseases
por: Arumugam, Madan Kumar, et al.
Publicado: (2023)

Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection
por: Dagur, Raghubendra Singh, et al.
Publicado: (2019)

Role of Ceramides and Lysosomes in Extracellular Vesicle Biogenesis, Cargo Sorting and Release
por: Horbay, Rostyslav, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2jvngaffuiksuagsinqh80h862