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The Insulin Receptor Mediates Insulin’s Early Plasma Clearance by Liver, Muscle, and Kidney

The role of the insulin receptor in mediating tissue-specific insulin clearance in vivo has not been reported. Using physiologic insulin doses, we measured the initial clearance rate (first 5 min) of intravenously injected ([(125)I]Tyr(A14))-insulin by muscle, liver, and kidney in healthy rats in th...

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Detalles Bibliográficos
Autores principales: Meijer, Rick I., Barrett, Eugene J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824884/
https://www.ncbi.nlm.nih.gov/pubmed/33466380
http://dx.doi.org/10.3390/biomedicines9010037