Cargando…

Impact of APOE ε4 genotype on initial cognitive symptoms differs for Alzheimer’s and Lewy body neuropathology

BACKGROUND: APOE ε4 carrier status is known to increase odds of amnestic presentations with Alzheimer’s pathology. It is unknown how APOE ε4 carrier status impacts odds of specific initial cognitive symptoms in the presence of Lewy body pathology. Here we evaluate the impact of APOE ε4 genotype on i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pillai, Jagan A., Bena, James, Bonner-Jackson, Aaron, Leverenz, James B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825215/ https://www.ncbi.nlm.nih.gov/pubmed/33485373 http://dx.doi.org/10.1186/s13195-021-00771-1

Ejemplares similares

Association of Variation in Behavioral Symptoms With Initial Cognitive Phenotype in Adults With Dementia Confirmed by Neuropathology
por: Pillai, Jagan A., et al.
Publicado: (2022)

APOE ε4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia
por: Mirza, Saira Saeed, et al.
Publicado: (2019)

Temporal Ordering of Inflammatory Analytes sTNFR2 and sTREM2 in Relation to Alzheimer's Disease Biomarkers and Clinical Outcomes
por: Pillai, Jagan A., et al.
Publicado: (2021)

APOE ε4, Alzheimer’s disease neuropathology and sleep disturbance, in individuals with and without dementia
por: Blackman, Jonathan, et al.
Publicado: (2022)

Outer Retinal Assessment Using Spectral-Domain Optical Coherence Tomography in Patients With Alzheimer's and Parkinson's Disease
por: Uchida, Atsuro, et al.
Publicado: (2018)

Inflammatory pathway analytes predicting rapid cognitive decline in MCI stage of Alzheimer’s disease
por: Pillai, Jagan A., et al.
Publicado: (2020)

Metabolic syndrome biomarkers relate to rate of cognitive decline in MCI and dementia stages of Alzheimer’s disease
por: Pillai, Jagan A., et al.
Publicado: (2023)

The Effects of CSF Neurogranin and APOE ε4 on Cognition and Neuropathology in Mild Cognitive Impairment and Alzheimer’s Disease
por: Fan, Yulan, et al.
Publicado: (2021)

Key inflammatory pathway activations in the MCI stage of Alzheimer’s disease
por: Pillai, Jagan A., et al.
Publicado: (2019)

APOE-ε4 and BIN1 increase risk of Alzheimer’s disease pathology but not specifically of Lewy body pathology
por: Talyansky, Seth, et al.
Publicado: (2023)

APOE-ε4 and BIN1 increase risk of Alzheimer’s disease pathology but not specifically of Lewy body pathology
por: Talyansky, Seth, et al.
Publicado: (2023)

TNFRSF1B Gene Variants and Related Soluble TNFR2 Levels Impact Resilience in Alzheimer's Disease
por: Pillai, Jagan A., et al.
Publicado: (2021)

Inflammation: Bridging Age, Menopause and APOEε4 Genotype to Alzheimer’s Disease
por: Mishra, Aarti, et al.
Publicado: (2018)

Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome
por: Arnold, Matthias, et al.
Publicado: (2020)

Fine particulate air pollution and neuropathology markers of Alzheimer’s disease in donors with and without APOE ε4 alleles – results from an autopsy cohort
por: Christensen, Grace M., et al.
Publicado: (2023)

Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer’s disease
por: Baek, Min Seok, et al.
Publicado: (2020)

APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer’s disease
por: Konijnenberg, Elles, et al.
Publicado: (2020)

Individual-specific functional connectivity improves prediction of Alzheimer’s disease’s symptoms in elderly people regardless of APOE ε4 genotype
por: Hua, Lin, et al.
Publicado: (2023)

Association between clinical symptoms and post‐mortem neuropathology in dementia with Lewy bodies
por: Kaneko, Yoshitsugu, et al.
Publicado: (2020)

GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study
por: Rongve, Arvid, et al.
Publicado: (2019)

Alzheimer's disease pathology explains association between dementia with Lewy bodies and APOE-ε4/TOMM40 long poly-T repeat allele variants
por: Prokopenko, Inga, et al.
Publicado: (2019)

Neuropathology-Independent Association Between APOE Genotype and Cognitive Decline Rate in the Normal Aging-Early Alzheimer Continuum
por: Qian, Jing, et al.
Publicado: (2023)

Severe hyposmia distinguishes neuropathologically confirmed dementia with Lewy bodies from Alzheimer’s disease dementia
por: Beach, Thomas G., et al.
Publicado: (2020)

Differential Neuropathology, Genetics, and Transcriptomics in Two Kindred Cases with Alzheimer’s Disease and Lewy Body Dementia
por: Palmieri, Ilaria, et al.
Publicado: (2022)

β-Amyloid PET and neuropathology in dementia with Lewy bodies
por: Kantarci, Kejal, et al.
Publicado: (2020)

Neuropathology of incidental Lewy body & prodromal Parkinson’s disease
por: Koeglsperger, Thomas, et al.
Publicado: (2023)

Impact of sex and APOE-ε4 genotype on patterns of regional brain atrophy in Alzheimer's disease and healthy aging
por: Sauty, Benoît, et al.
Publicado: (2023)

The Media Coverage of Bruce Willis Reveals Unfamiliarity With Frontotemporal Degeneration
por: Hurley, Robert S, et al.
Publicado: (2023)

The APOE(ε3/ε4) Genotype Drives Distinct Gene Signatures in the Cortex of Young Mice
por: Foley, Kate E., et al.
Publicado: (2022)

APOE genotype and Alzheimer’s immunotherapy
por: Pankiewicz, Joanna E., et al.
Publicado: (2017)

The Application of Zonisamide to Patients Suffering from Dementia with Lewy Bodies: Emerging Clinical Data
por: Tousi, Babak, et al.
Publicado: (2021)

Association of APOE Serum Levels and APOE ε2, ε3, and ε4 Alleles with Optic Neuritis
por: Momkute, Liucija, et al.
Publicado: (2022)

Proteomic Network Analysis of Alzheimer’s Disease Cerebrospinal Fluid Reveals Alterations Associated with APOE ε4 Genotype and Atomoxetine Treatment
por: Dammer, Eric B., et al.
Publicado: (2023)

Author Correction: GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study
por: Rongve, Arvid, et al.
Publicado: (2019)

APOE ε4, an Alzheimer’s disease susceptibility allele, and smoking cessation
por: Ashare, Rebecca L., et al.
Publicado: (2012)

Age‐dependent effects of APOE ε4 in preclinical Alzheimer's disease
por: Bonham, Luke W., et al.
Publicado: (2016)

APOEε4 and risk of Alzheimer’s disease – time to move forward
por: Lefterov, Iliya, et al.
Publicado: (2023)

Neuropathological Changes in Dementia With Lewy Bodies and the Cingulate Island Sign
por: Patterson, Lina, et al.
Publicado: (2019)

Apolipoprotein E ε2 genotype delays onset of dementia with Lewy bodies in a Norwegian cohort
por: Berge, Guro, et al.
Publicado: (2014)

APOEε4 Genotype Is Related to Brain Amyloid Among Mexican Americans in the HABS-HD Study
por: O'Bryant, Sid E., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_7st2hv69uojlvbdiepan4fl1nf