In situ immunogenic clearance induced by a combination of photodynamic therapy and rho-kinase inhibition sensitizes immune checkpoint blockade response to elicit systemic antitumor immunity against intraocular melanoma and its metastasis

BACKGROUND: Uveal melanoma (UM) is the most frequent intraocular malignancy and is resistant to immunotherapy. Nearly 50% of patients with UM develop metastatic disease, and the overall survival outcome remains very poor. Therefore, a treatment regimen that simultaneously targets primary UM and prev...

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Detalles Bibliográficos
Autores principales: Kim, Seohyun, Kim, Seong A, Nam, Gi-Hoon, Hong, Yeonsun, Kim, Gi Beom, Choi, Yoonjeong, Lee, Seokyoung, Cho, Yuri, Kwon, Minsu, Jeong, Cherlhyun, Kim, Sehoon, Kim, In-San
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825261/
https://www.ncbi.nlm.nih.gov/pubmed/33479026
http://dx.doi.org/10.1136/jitc-2020-001481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825261/
https://www.ncbi.nlm.nih.gov/pubmed/33479026
http://dx.doi.org/10.1136/jitc-2020-001481

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