Genetics and Genomics of SOST: Functional Analysis of Variants and Genomic Regulation in Osteoblasts

SOST encodes the sclerostin protein, which acts as a key extracellular inhibitor of the canonical Wnt pathway in bone, playing a crucial role in skeletal development and bone homeostasis. The objective of this work was to assess the functionality of two variants previously identified (the rare varia...

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Detalles Bibliográficos
Autores principales: Martínez-Gil, Núria, Roca-Ayats, Neus, Cozar, Mónica, Garcia-Giralt, Natàlia, Ovejero, Diana, Nogués, Xavier, Grinberg, Daniel, Balcells, Susanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825314/
https://www.ncbi.nlm.nih.gov/pubmed/33419004
http://dx.doi.org/10.3390/ijms22020489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825314/
https://www.ncbi.nlm.nih.gov/pubmed/33419004
http://dx.doi.org/10.3390/ijms22020489

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