Design Strategy for the EPR Tumor-Targeting of 1,2-Bis(sulfonyl)-1-alkylhydrazines

A design strategy for macromolecular prodrugs is described, that are expected to exhibit robust activity against most solid tumor types while resulting in minimal toxicities to normal tissues. This approach exploits the enhanced permeability, and retention (EPR) effect, and utilizes carefully engine...

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Detalles Bibliográficos
Autores principales: Penketh, Philip G., Williamson, Hugh S., Baumann, Raymond P., Shyam, Krishnamurthy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825511/
https://www.ncbi.nlm.nih.gov/pubmed/33419160
http://dx.doi.org/10.3390/molecules26020259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825511/
https://www.ncbi.nlm.nih.gov/pubmed/33419160
http://dx.doi.org/10.3390/molecules26020259

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