Improved Manufacturability and In Vivo Comparative Pharmacokinetics of Dapagliflozin Cocrystals in Beagle Dogs and Human Volunteers

Dapagliflozin (DAP), which improves glycemic control in patients with type 2 diabetes mellitus, has poor physical properties against heat and moisture, thus hindering its manufacturing potential. The superior physicochemical properties of a recently developed cocrystal of DAP and citric acid (DAP co...

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Detalles Bibliográficos
Autores principales: Cho, Sangho, Lee, Jeongwook, Yoo, Yongwon, Cho, Minyong, Sohn, Seil, Lee, Beom-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825777/
https://www.ncbi.nlm.nih.gov/pubmed/33430328
http://dx.doi.org/10.3390/pharmaceutics13010070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825777/
https://www.ncbi.nlm.nih.gov/pubmed/33430328
http://dx.doi.org/10.3390/pharmaceutics13010070

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