Human SIRT1 Multispecificity Is Modulated by Active-Site Vicinity Substitutions during Natural Evolution

Many enzymes that catalyze protein post-translational modifications can specifically modify multiple target proteins. However, little is known regarding the molecular basis and evolution of multispecificity in these enzymes. Here, we used a combined bioinformatics and experimental approaches to inve...

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Detalles Bibliográficos
Autores principales: Hendler, Adi, Akiva, Eyal, Sandhu, Mahakaran, Goldberg, Dana, Arbely, Eyal, Jackson, Colin J, Aharoni, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826192/
https://www.ncbi.nlm.nih.gov/pubmed/32956445
http://dx.doi.org/10.1093/molbev/msaa244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826192/
https://www.ncbi.nlm.nih.gov/pubmed/32956445
http://dx.doi.org/10.1093/molbev/msaa244

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