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Human SIRT1 Multispecificity Is Modulated by Active-Site Vicinity Substitutions during Natural Evolution
Many enzymes that catalyze protein post-translational modifications can specifically modify multiple target proteins. However, little is known regarding the molecular basis and evolution of multispecificity in these enzymes. Here, we used a combined bioinformatics and experimental approaches to inve...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826192/ https://www.ncbi.nlm.nih.gov/pubmed/32956445 http://dx.doi.org/10.1093/molbev/msaa244 |