A deafness-associated tRNA mutation caused pleiotropic effects on the m(1)G37 modification, processing, stability and aminoacylation of tRNA(Ile) and mitochondrial translation

Defects in the posttranscriptional modifications of mitochondrial tRNAs have been linked to human diseases, but their pathophysiology remains elusive. In this report, we investigated the molecular mechanism underlying a deafness-associated tRNA(Ile) 4295A>G mutation affecting a highly conserved a...

Descripción completa

Detalles Bibliográficos
Autores principales: Meng, Feilong, Zhou, Mi, Xiao, Yun, Mao, Xiaoting, Zheng, Jing, Lin, Jiaxi, Lin, Tianxiang, Ye, Zhenzhen, Cang, Xiaohui, Fu, Yong, Wang, Meng, Guan, Min-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826259/
https://www.ncbi.nlm.nih.gov/pubmed/33398350
http://dx.doi.org/10.1093/nar/gkaa1225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826259/
https://www.ncbi.nlm.nih.gov/pubmed/33398350
http://dx.doi.org/10.1093/nar/gkaa1225

Ejemplares similares