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A hotspot for enhancing insulin receptor activation revealed by a conformation-specific allosteric aptamer
Aptamers are single-stranded oligonucleotides that bind to a specific target with high affinity, and are widely applied in biomedical diagnostics and drug development. However, the use of aptamers has largely been limited to simple binders or inhibitors that interfere with the function of a target p...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826266/ https://www.ncbi.nlm.nih.gov/pubmed/33410883 http://dx.doi.org/10.1093/nar/gkaa1247 |