Pseudomonas putida MPE, a manganese-dependent endonuclease of the binuclear metallophosphoesterase superfamily, incises single-strand DNA in two orientations to yield a mixture of 3′-PO(4) and 3′-OH termini

Pseudomonas putida MPE exemplifies a novel clade of manganese-dependent single-strand DNA endonuclease within the binuclear metallophosphoesterase superfamily. MPE is encoded within a widely conserved DNA repair operon. Via structure-guided mutagenesis, we identify His113 and His81 as essential for...

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Detalles Bibliográficos
Autores principales: Ghosh, Shreya, Ejaz, Anam, Repeta, Lucas, Shuman, Stewart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826289/
https://www.ncbi.nlm.nih.gov/pubmed/33367848
http://dx.doi.org/10.1093/nar/gkaa1214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826289/
https://www.ncbi.nlm.nih.gov/pubmed/33367848
http://dx.doi.org/10.1093/nar/gkaa1214

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