The high-affinity immunoglobulin receptor FcγRI potentiates HIV-1 neutralization via antibodies against the gp41 N-heptad repeat

The HIV-1 gp41 N-heptad repeat (NHR) region of the prehairpin intermediate, which is transiently exposed during HIV-1 viral membrane fusion, is a validated clinical target in humans and is inhibited by the Food and Drug Administration (FDA)-approved drug enfuvirtide. However, vaccine candidates targ...

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Detalles Bibliográficos
Autores principales: Montefiori, David C., Filsinger Interrante, Maria V., Bell, Benjamin N., Rubio, Adonis A., Joyce, Joseph G., Shiver, John W., LaBranche, Celia C., Kim, Peter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826338/
https://www.ncbi.nlm.nih.gov/pubmed/33431684
http://dx.doi.org/10.1073/pnas.2018027118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826338/
https://www.ncbi.nlm.nih.gov/pubmed/33431684
http://dx.doi.org/10.1073/pnas.2018027118

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