The harsh microenvironment in early breast cancer selects for a Warburg phenotype

The harsh microenvironment of ductal carcinoma in situ (DCIS) exerts strong evolutionary selection pressures on cancer cells. We hypothesize that the poor metabolic conditions near the ductal center foment the emergence of a Warburg Effect (WE) phenotype, wherein cells rapidly ferment glucose to lac...

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Detalles Bibliográficos
Autores principales: Damaghi, Mehdi, West, Jeffrey, Robertson-Tessi, Mark, Xu, Liping, Ferrall-Fairbanks, Meghan C., Stewart, Paul A., Persi, Erez, Fridley, Brooke L., Altrock, Philipp M., Gatenby, Robert A., Sims, Peter A., Anderson, Alexander R. A., Gillies, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826394/
https://www.ncbi.nlm.nih.gov/pubmed/33452133
http://dx.doi.org/10.1073/pnas.2011342118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826394/
https://www.ncbi.nlm.nih.gov/pubmed/33452133
http://dx.doi.org/10.1073/pnas.2011342118

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