Small-molecule endoplasmic reticulum proteostasis regulator acts as a broad-spectrum inhibitor of dengue and Zika virus infections

Flaviviruses, including dengue and Zika, are widespread human pathogens; however, no broadly active therapeutics exist to fight infection. Recently, remodeling of endoplasmic reticulum (ER) proteostasis by pharmacologic regulators, such as compound 147, was shown to correct pathologic ER imbalances...

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Detalles Bibliográficos
Autores principales: Almasy, Katherine M., Davies, Jonathan P., Lisy, Samantha M., Tirgar, Reyhaneh, Tran, Sirena C., Plate, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826409/
https://www.ncbi.nlm.nih.gov/pubmed/33441483
http://dx.doi.org/10.1073/pnas.2012209118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826409/
https://www.ncbi.nlm.nih.gov/pubmed/33441483
http://dx.doi.org/10.1073/pnas.2012209118

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