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Physiological role of the 3′IgH CBEs super-anchor in antibody class switching
IgH class switch recombination (CSR) replaces Cμ constant region (C(H)) exons with one of six downstream C(H)s by joining transcription-targeted double-strand breaks (DSBs) in the Cμ switch (S) region to DSBs in a downstream S region. Chromatin loop extrusion underlies fundamental CSR mechanisms inc...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826415/ https://www.ncbi.nlm.nih.gov/pubmed/33441485 http://dx.doi.org/10.1073/pnas.2024392118 |