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Physiological role of the 3′IgH CBEs super-anchor in antibody class switching

IgH class switch recombination (CSR) replaces Cμ constant region (C(H)) exons with one of six downstream C(H)s by joining transcription-targeted double-strand breaks (DSBs) in the Cμ switch (S) region to DSBs in a downstream S region. Chromatin loop extrusion underlies fundamental CSR mechanisms inc...

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Detalles Bibliográficos
Autores principales:	Zhang, Xuefei, Yoon, Hye Suk, Chapdelaine-Williams, Aimee M., Kyritsis, Nia, Alt, Frederick W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2021
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826415/ https://www.ncbi.nlm.nih.gov/pubmed/33441485 http://dx.doi.org/10.1073/pnas.2024392118

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