Cargando…

Ultra‐mutated colorectal cancer patients with POLE driver mutations exhibit distinct clinical patterns

POLE mutations, which lead to an ultramutated phenotype in colorectal cancer (CRC), have been reported as a promising marker in immunotherapy. We performed sequencing of CRC cases in Zhejiang University (ZJU) and extracted obtainable data from recently published results, including The Cancer Genome...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Hanguang, Cai, Wen, Wu, Dehao, Hu, Wangxiong, Dong Wang, Li, Mao, Jianshan, Zheng, Shu, Ge, Weiting
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Clinical Cancer Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826451/ https://www.ncbi.nlm.nih.gov/pubmed/33125191 http://dx.doi.org/10.1002/cam4.3579

Ejemplares similares

Rectal NETs and rectosigmoid junction NETs may need to be treated differently
por: Cai, Wen, et al.
Publicado: (2019)

A novel 4-gene prognostic signature for hypermutated colorectal cancer
por: Ge, Weiting, et al.
Publicado: (2019)

Primary tumor location (right versus left side of the colon) and resection affect the survival of patients with liver metastases from colonic neuroendocrine carcinoma: a population-based study
por: Cai, Wen, et al.
Publicado: (2021)

POLE somatic mutations in advanced colorectal cancer
por: Guerra, Joana, et al.
Publicado: (2017)

Clinicopathological and mutational analyses of colorectal cancer with mutations in the POLE gene
por: Hino, Hitoshi, et al.
Publicado: (2019)

Pattern and risk factors for distant metastases in gastrointestinal neuroendocrine neoplasms: a population‐based study
por: Cai, Wen, et al.
Publicado: (2018)

Mutations in POLE and survival of colorectal cancer patients – link to disease stage and treatment
por: Stenzinger, Albrecht, et al.
Publicado: (2014)

Subtyping of microsatellite instability-high colorectal cancer
por: Hu, Wangxiong, et al.
Publicado: (2019)

Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer
por: Fang, Hu, et al.
Publicado: (2020)

EGFR Target Therapy Combined with Gemox for Advanced Biliary Tract Cancers: a Meta-analysis based on RCTs
por: Cai, Wen, et al.
Publicado: (2018)

A 10-year Population-based Study of the Differences between NECs and Carcinomas of the Esophagus in Terms of Clinicopathology and Survival
por: Cai, Wen, et al.
Publicado: (2019)

Factors Affecting the Outcomes of Patients with Malignant Rhabdoid Tumors: A Population-Based Study
por: Cai, Wen, et al.
Publicado: (2021)

Pan-cancer analyses demonstrate that ANKRD6 is associated with a poor prognosis and correlates with M2 macrophage infiltration in colon cancer
por: Bai, Rui, et al.
Publicado: (2021)

Distinct mutational profile and immune microenvironment in microsatellite-unstable and POLE-mutated tumors
por: Hwang, Hee Sang, et al.
Publicado: (2021)

Deciphering molecular properties of hypermutated gastrointestinal cancer
por: Hu, Wangxiong, et al.
Publicado: (2018)

Highly sensitive detection of driver mutations from cytological samples and cfDNA in lung cancer
por: Fujita, Kazutaka, et al.
Publicado: (2021)

Distinct clinical pattern of colorectal cancer patients with POLE mutations: A retrospective study on real-world data
por: Jiang, Miao, et al.
Publicado: (2022)

A Retrospective Exploration of Targeted Maintenance Therapy in Advanced Colorectal Cancer: Based on the Background of Chinese Patient Assistance Program
por: Hu, Hanguang, et al.
Publicado: (2020)

Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response
por: Temko, Daniel, et al.
Publicado: (2018)

Dynamic changes of driver genes’ mutations across clinical stages in nine cancer types
por: Li, Xia
Publicado: (2016)

Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy
por: Springer, Simeon U, et al.
Publicado: (2018)

Association mining of mutated cancer genes in different clinical stages across 11 cancer types
por: Hu, Wangxiong, et al.
Publicado: (2016)

Correction: Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy
por: Springer, Simeon U, et al.
Publicado: (2018)

Mutations in Noncoding Cis-Regulatory Elements Reveal Cancer Driver Cistromes in Luminal Breast Cancer
por: El Ghamrasni, Samah, et al.
Publicado: (2022)

Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromes
por: Spinelli, Laura, et al.
Publicado: (2015)

Mathematical modeling the order of driver gene mutations in colorectal cancer
por: Li, Lingling, et al.
Publicado: (2023)

Early‐onset triple‐negative breast cancer in multiracial/ethnic populations: Distinct trends of prevalence of truncation mutations
por: Liu, Qian, et al.
Publicado: (2019)

Hypoxia Confers Tumor with a Higher Immune Infiltration but Lower Mutation Burden in Gastrointestinal Cancer
por: Hu, Junjie, et al.
Publicado: (2022)

ATM Mutations Associate with Distinct Co-Mutational Patterns and Therapeutic Vulnerabilities in NSCLC
por: Vokes, Natalie I., et al.
Publicado: (2023)

Sporadic multiple meningiomas harbor distinct driver mutations
por: Juratli, Tareq A., et al.
Publicado: (2021)

Risk of colorectal cancer for carriers of a germline mutation in POLE or POLD1
por: Buchanan, Daniel D., et al.
Publicado: (2017)

Clinical and epigenetic features of colorectal cancer patients with somatic POLE proofreading mutations
por: Kawai, Takashi, et al.
Publicado: (2021)

Non-coding cancer driver candidates identified with a sample- and position-specific model of the somatic mutation rate
por: Juul, Malene, et al.
Publicado: (2017)

Phenotype of POLE-mutated endometrial cancer
por: Imboden, Sara, et al.
Publicado: (2019)

Gene mutation profiling in Chinese colorectal cancer patients and its association with clinicopathological characteristics and prognosis
por: Ye, Zu‐Lu, et al.
Publicado: (2019)

Identification of novel mutations and functional impacts of EPAS1 in colorectal cancer
por: Islam, Farhadul, et al.
Publicado: (2021)

PEG3 mutation is associated with elevated tumor mutation burden and poor prognosis in breast cancer
por: Zhang, Min, et al.
Publicado: (2020)

Genome analysis of peeling archival cytology samples detects driver mutations in lung cancer
por: Kunimasa, Kei, et al.
Publicado: (2020)

Analysis of potential genes and pathways associated with the colorectal normal mucosa–adenoma–carcinoma sequence
por: Wu, Zhuoxuan, et al.
Publicado: (2018)

Targeted Next-Generation Sequencing Reveals Exceptionally High Rates of Molecular Driver Mutations in Never-Smokers With Lung Adenocarcinoma
por: Mack, Philip C, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_faa9s6ujg93tq5qvh0duv315g4