Functional and genomic characterization of patient‐derived xenograft model to study the adaptation to mTORC1 inhibitor in clear cell renal cell carcinoma

Resistance to the mechanistic target of rapamycin (mTOR) inhibitors, which are a standard treatment for advanced clear cell renal cell carcinoma (ccRCC), eventually develops in most cases. In this study, we established a patient‐derived xenograft (PDX) model which acquired resistance to the mTOR inh...

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Detalles Bibliográficos
Autores principales: Sakamoto, Hiromasa, Yamasaki, Toshinari, Sumiyoshi, Takayuki, Takeda, Masashi, Shibasaki, Noboru, Utsunomiya, Noriaki, Arakaki, Ryuichiro, Akamatsu, Shusuke, Kobayashi, Takashi, Inoue, Takahiro, Kamba, Tomomi, Nakamura, Eijiro, Ogawa, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Clinical Cancer Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826464/
https://www.ncbi.nlm.nih.gov/pubmed/33107222
http://dx.doi.org/10.1002/cam4.3578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826464/
https://www.ncbi.nlm.nih.gov/pubmed/33107222
http://dx.doi.org/10.1002/cam4.3578

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