Targeting a Lipid Desaturation Enzyme, SCD1, Selectively Eliminates Colon Cancer Stem Cells through the Suppression of Wnt and NOTCH Signaling

The elimination of the cancer stem cell (CSC) population may be required to achieve better outcomes of cancer therapy. We evaluated stearoyl-CoA desaturase 1 (SCD1) as a novel target for CSC-selective elimination in colon cancer. CSCs expressed more SCD1 than bulk cultured cells (BCCs), and blocking...

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Detalles Bibliográficos
Autores principales: Yu, Yeongji, Kim, Hyejin, Choi, SeokGyeong, Yu, JinSuh, Lee, Joo Yeon, Lee, Hani, Yoon, Sukjoon, Kim, Woo-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826607/
https://www.ncbi.nlm.nih.gov/pubmed/33430034
http://dx.doi.org/10.3390/cells10010106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826607/
https://www.ncbi.nlm.nih.gov/pubmed/33430034
http://dx.doi.org/10.3390/cells10010106

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