Acute D-Serine Co-Agonism of β-Cell NMDA Receptors Potentiates Glucose-Stimulated Insulin Secretion and Excitatory β-Cell Membrane Activity

Insulin-secreting pancreatic β-cells express proteins characteristic of D-serine regulated synapses, but the acute effect of D-serine co-agonism on its presumptive β-cell target, N-methyl D-aspartate receptors (NMDARs), is unclear. We used multiple models to evaluate glucose homeostasis and insulin...

Descripción completa

Detalles Bibliográficos
Autores principales: Lockridge, Amber, Gustafson, Eric, Wong, Alicia, Miller, Robert F., Alejandro, Emilyn U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826616/
https://www.ncbi.nlm.nih.gov/pubmed/33430405
http://dx.doi.org/10.3390/cells10010093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826616/
https://www.ncbi.nlm.nih.gov/pubmed/33430405
http://dx.doi.org/10.3390/cells10010093

Ejemplares similares