Glucose 6-Phosphate Dehydrogenase from Trypanosomes: Selectivity for Steroids and Chemical Validation in Bloodstream Trypanosoma brucei

Glucose 6-phosphate dehydrogenase (G6PDH) fulfills an essential role in cell physiology by catalyzing the production of NADPH(+) and of a precursor for the de novo synthesis of ribose 5-phosphate. In trypanosomatids, G6PDH is essential for in vitro proliferation, antioxidant defense and, thereby, dr...

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Detalles Bibliográficos
Autores principales: Ortíz, Cecilia, Moraca, Francesca, Laverriere, Marc, Jordan, Allan, Hamilton, Niall, Comini, Marcelo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826790/
https://www.ncbi.nlm.nih.gov/pubmed/33445584
http://dx.doi.org/10.3390/molecules26020358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826790/
https://www.ncbi.nlm.nih.gov/pubmed/33445584
http://dx.doi.org/10.3390/molecules26020358

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