Sugar Matters: Improving In Vivo Clearance Rate of Highly Glycosylated Recombinant Plasma Proteins for Therapeutic Use

Correct glycosylation of proteins is essential for production of therapeutic proteins as glycosylation is important for protein solubility, stability, half-life and immunogenicity. The heavily glycosylated plasma protein C1-inhibitor (C1-INH) is used in treatment of hereditary angioedema attacks. In...

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Detalles Bibliográficos
Autores principales: Zeerleder, Sacha, Engel, Ruchira, Zhang, Tao, Roem, Dorina, van Mierlo, Gerard, Wagenaar-Bos, Ineke, van Ham, Sija Marieke, Wuhrer, Manfred, Wouters, Diana, Jongerius, Ilse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826800/
https://www.ncbi.nlm.nih.gov/pubmed/33440845
http://dx.doi.org/10.3390/ph14010054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826800/
https://www.ncbi.nlm.nih.gov/pubmed/33440845
http://dx.doi.org/10.3390/ph14010054

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