Thymic Stromal Lymphopoietin Promotes MRGPRX2-Triggered Degranulation of Skin Mast Cells in a STAT5-Dependent Manner with Further Support from JNK

Thymic stromal lymphopoietin (TSLP) is released by epithelial cells following disturbed homeostasis to act as “alarmin” and driver of Th2-immunity. Aberrant TSLP expression is a hallmark of atopic diseases, including atopic dermatitis (AD). Mast cells (MCs) are overabundant in AD lesions and show si...

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Detalles Bibliográficos
Autores principales: Babina, Magda, Wang, Zhao, Franke, Kristin, Zuberbier, Torsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826995/
https://www.ncbi.nlm.nih.gov/pubmed/33429916
http://dx.doi.org/10.3390/cells10010102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826995/
https://www.ncbi.nlm.nih.gov/pubmed/33429916
http://dx.doi.org/10.3390/cells10010102

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