Cargando…

Functional T Cell Reactivity to Melanocyte Antigens Is Lost during the Progression of Malignant Melanoma, but Is Restored by Immunization

SIMPLE SUMMARY: Healthy humans develop spontaneous CD8+ T cell responses to melanoma associated antigens (MA) expressed by normal melanocytes. This natural autoimmunity directed against melanocytes might confer protection against the development of malignant melanoma (MM), where MA are overexpressed...

Descripción completa

Detalles Bibliográficos
Autores principales:	Przybyla, Anna, Lehmann, Alexander A., Zhang, Ting, Mackiewicz, Jacek, Galus, Łukasz, Kirchenbaum, Greg A., Mackiewicz, Andrzej, Lehmann, Paul V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827050/ https://www.ncbi.nlm.nih.gov/pubmed/33435427 http://dx.doi.org/10.3390/cancers13020223

Ejemplares similares

Oncogenic BRAF mutations and p16 expression in melanocytic nevi and melanoma in the Polish population
por: Mackiewicz-Wysocka, Małgorzata, et al.
Publicado: (2017)

Therapeutic melanoma vaccine with cancer stem cell phenotype represses exhaustion and maintains antigen-specific T cell stemness by up-regulating BCL6
por: Czerwinska, Patrycja, et al.
Publicado: (2020)

Myeloid-Derived Suppressor Cells (MDSC) in Melanoma Patients Treated with Anti-PD-1 Immunotherapy
por: Tomela, Katarzyna, et al.
Publicado: (2023)

Whole cell melanoma vaccine genetically modified to stem cells like phenotype generates specific immune responses to ALDH1A1 and long-term survival in advanced melanoma patients
por: Kwiatkowska-Borowczyk, Eliza, et al.
Publicado: (2018)

A Clinical Outcome of the Anti-PD-1 Therapy of Melanoma in Polish Patients Is Mediated by Population-Specific Gut Microbiome Composition
por: Pietrzak, Bernadeta, et al.
Publicado: (2022)

BRAF and MEK inhibitors in the era of immunotherapy in melanoma patients
por: Mackiewicz, Jacek, et al.
Publicado: (2018)

Analysis of sequence variants in the 3'UTR of CDKN2A gene in melanoma patients
por: Przybyła, Anna, et al.
Publicado: (2015)

Programmed cell death 1 checkpoint inhibitors in the treatment of patients with advanced melanoma
por: Mackiewicz, Jacek, et al.
Publicado: (2017)

Recent advances in melanoma treatment – American Society of Clinical Oncology (ASCO) 2012 perspective
por: Mackiewicz, Jacek, et al.
Publicado: (2012)

Circulating Melanoma Cell Numbers Correlate with TIGIT-Positive Cytotoxic T Cell Counts in Advanced-Stage Melanoma Patients
por: Kamińska, Paula, et al.
Publicado: (2023)

Resistance to Vemurafenib Can Be Reversible After Treatment Interruption: A Case Report of a Metastatic Melanoma Patient
por: Mackiewicz-Wysocka, Małgorzata, et al.
Publicado: (2014)

Plasma lncRNA expression profile as a prognostic tool in BRAF-mutant metastatic melanoma patients treated with BRAF inhibitor
por: Kolenda, Tomasz, et al.
Publicado: (2019)

Re-induction using whole cell melanoma vaccine genetically modified to melanoma stem cells-like beyond recurrence extends long term survival of high risk resected patients - updated results
por: Mackiewicz, Jacek, et al.
Publicado: (2018)

Deconvoluting the T Cell Response to SARS-CoV-2: Specificity Versus Chance and Cognate Cross-Reactivity
por: Lehmann, Alexander A., et al.
Publicado: (2021)

What is new in the treatment of advanced melanoma? State of the art
por: Mackiewicz, Jacek
Publicado: (2012)

Surface antigens of melanocytes and melanomas. Markers of melanocyte differentiation and melanoma subsets
Publicado: (1982)

From Melanocyte to Malignant Metastatic Melanoma
por: Manga, Prashiela, et al.
Publicado: (2010)

IL-21 in Conjunction with Anti-CD40 and IL-4 Constitutes a Potent Polyclonal B Cell Stimulator for Monitoring Antigen-Specific Memory B Cells
por: Franke, Fridolin, et al.
Publicado: (2020)

From Melanocyte to Metastatic Malignant Melanoma
por: Bandarchi, Bizhan, et al.
Publicado: (2010)

Efficacy and safety of ipilimumab therapy in patients with metastatic melanoma: a retrospective multicenter analysis
por: Wiater, Katarzyna, et al.
Publicado: (2013)

Whole Cell Therapeutic Vaccine Modified With Hyper-IL6 for Combinational Treatment of Nonresected Advanced Melanoma
por: Jacek, Mackiewicz, et al.
Publicado: (2015)

The mystery of let-7d – a small RNA with great power
por: Kolenda, Tomasz, et al.
Publicado: (2014)

A Novel and Effective Method for Human Primary Skin Melanocytes and Metastatic Melanoma Cell Isolation
por: Ścieżyńska, Aneta, et al.
Publicado: (2021)

Melanocytic Matricoma: A Potential Mimic of Malignant Melanoma
por: Yablonski, John, et al.
Publicado: (2023)

Interference of COVID-19 Vaccination With PET/CT Leads to Unnecessary Additional Imaging in a Patient With Metastatic Cutaneous Melanoma—Case Report
por: Czepczyński, Rafał, et al.
Publicado: (2021)

Histopathological diagnosis of small melanocytic lesions suspicious for malignant melanoma
por: Quintella, Danielle Carvalho, et al.
Publicado: (2017)

The Tumor and Host Immune Signature, and the Gut Microbiota as Predictive Biomarkers for Immune Checkpoint Inhibitor Response in Melanoma Patients
por: Tomela, Katarzyna, et al.
Publicado: (2020)

Wound fluids affect miR-21, miR-155 and miR-221 expression in breast cancer cell lines, and this effect is partially abrogated by intraoperative radiation therapy treatment
por: Zaleska, Karolina, et al.
Publicado: (2017)

Cell surface antigens of human melanocytes and melanoma. Expression of adenosine deaminase binding protein is extinguished with melanocyte transformation
Publicado: (1988)

Surface antigens of melanoma and melanocytes. Specificity of induction of Ia antigens by human gamma-interferon
Publicado: (1984)

Long-Term Real-World Outcomes and Safety of Vemurafenib and Vemurafenib + Cobimetinib Therapy in Patients with BRAF-Mutated Melanoma
por: Piejko, Karolina, et al.
Publicado: (2023)

Affinity Tag Coating Enables Reliable Detection of Antigen-Specific B Cells in Immunospot Assays
por: Köppert, Sebastian, et al.
Publicado: (2021)

CKS1 expression in melanocytic nevi and melanoma
por: Brożyna, Anna A., et al.
Publicado: (2017)

Suppression of properties associated with malignancy in murine melanoma-melanocyte hybrid cells.
por: Wakeling, W. F., et al.
Publicado: (1992)

Melanoma in congenital melanocytic naevi
por: Kinsler, V.A., et al.
Publicado: (2017)

Comprehensive Evaluation of the Expressed CD8+ T Cell Epitope Space Using High-Throughput Epitope Mapping
por: Lehmann, Paul V., et al.
Publicado: (2019)

lncRNA Expression after Irradiation and Chemoexposure of HNSCC Cell Lines
por: Guglas, Kacper, et al.
Publicado: (2018)

Oncogenic Role of ZFAS1 lncRNA in Head and Neck Squamous Cell Carcinomas
por: Kolenda, Tomasz, et al.
Publicado: (2019)

LATS1 Is a Mediator of Melanogenesis in Response to Oxidative Stress and Regulator of Melanoma Growth
por: Kazimierczak, Urszula, et al.
Publicado: (2021)

Melanoma Risk and Melanocyte Biology
por: BERTRAND, Juliette U., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_cn24idp46lnj5pkndc5gl6v072